Your infusion nurse will reach out to you and schedule your infusion, based on your preferred availability and location. Naturopathic medical doctors Mark Stengler and Paul Anderson focus on the most critical components of Integrative Oncology Care. Humira. Found insideThe new book entitled Development of Biopharmaceutical Drug Device Products is a reference text for scientists and engineers in the biopharmaceutical industry, academia or regulatory agencies. (And we have a Discord: https://discord.gg/g2gcwb6), Press J to jump to the feed. Stelara has different types of administration. Remicade. Induction dose: A single IV infusion using a weight-based dosage regimen: STELARA 260 mg (weight 55 kg), STELARA 390 mg (weight >55 kg to 85 kg), STELARA 520 mg (weight >85 kg). Maintenance dose: A subQ 90-mg dose administered every 8 weeks after the induction dose. Now I just have to stay on my regimen every 8 weeks. Stelara is STELARA is a prescription medicine that is used to treat: adults and paediatric patients (children and adolescents) 6 years and older with moderate to severe plaque psoriasis that is chronic (doesn't go away), adults with active psoriatic arthritis, an inflammatory disease of the joints that is usually accompanied by psoriasis, It was followed 8 weeks later by a Maintenance study (UNIFI-M) where patients received STELARA 90 mg subcutaneous (SC) injections every 8 weeks for 44 weeks. When using Stelara to treat Crohns Disease or Ulcerative Colitis, your treatment starts with a one-time IV infusion. #32. JavaScript is disabled. I know I'm late on this but I had my first infusion a month and a half ago and it was so easy. For RA, I can think of three biologics - Simponi (subq) and Simponi Aria (IV), Orencia (subq or IV) and Actemra (subq or IV). Stelara Infusion & Ganglionectomy Pain It Could Be Worse Mary Horsley. Here is what you can expect when you refer your patients to our infusion suite You must log in or register to reply here. Couple this with the first edition, published in 2004, and there are no other publications that more thoroughly discuss this technology! CD=Crohn's disease; IV=intravenous; subQ=subcutaneous; UC=ulcerative colitis. Found inside Page iThis is followed by a systematic coverage of drugs affecting the immune system, including natural products. Iron stores can take a very long time to get back up even with mucousal healing. skin rash or itching. doctorfoster. For a better experience, please enable JavaScript in your browser before proceeding. There are 6 injections during your first year of treatment. I finally got insurance approval for the Stelara infusion. A Stelara infusion. After you complete your infusion, the administration of Stelara will change from an infusion to an injection. Calculate the dose and the number of STELARA vials needed based on patient weight (see section 4.2, Table 1). Use only an infusion set with an in-line, sterile, non-pyrogenic, low protein-binding filter (pore size 0.2 micrometer). So just be sure to temper your expectations! Simponi and Simponi Aria. Feeling the same, was tired the day of and the day after but not much more tired than I usually am. Official Websites: https://www.stelarainfo.com, Ulcerative Colitis: https://www.stelarainfo.com/ulcerative-colitis, Crohns Disease: https://www.stelarainfo.com/crohns-disease, Psoriatic Arthritis: https://www.stelarainfo.com/psoriatic-arthritis, Plaque Psoriasis: https://www.stelarainfo.com/plaque-psoriasis. Found inside Page iThe Dermatology Handbook provides clinical information and quick solutions to common problems typically faced by dermatologists in a user-friendly and meaningful way. Well, I called to schedule my infusion and the nurse said don't worry because they can stop the infusion any time and can use steroids and/or antihistamines to immediately reverse any adverse reactions. A doctor may prescribe the medication ustekinumab (Stelara), which is a one-time infusion. I am hopeful because the bleeding has significantly decreased, but the rest of my issues are still here for now. A single intravenous infusion dose of STELARA using the weight-based dosage regimen specified in Table [see Instructions for dilution of STELARA 1 130 mg vial for intravenous infusion (2.6)]. Also, my son's GI said that it can take 6-9 months for Stelara to reach its maximum effectiveness so it may be too soon to know if Stelara is doing all that you need! I took the day off and worked half days the rest of the week. When using Stelara to treat Crohns Disease or Ulcerative Colitis, your treatment starts with a one-time IV infusion. Stelara has an average rating of 5.8 out of 10 from a total of 32 ratings for the treatment of Crohn's Disease. Pediatric Inflammatory Bowel Disease, Second Edition provides an essential reference with an emphasis on the unique pediatric issues of IBD. Chapters focus on complications of IBD specific to children and adolescents. The FDA asked the IOM to review aspects of pediatric studies and changes in product labeling that resulted from BPCA and PREA and their predecessor policies, as well as assess the incentives for pediatric studies of biologics and the extent Filter by condition. Once we receive this information, we verify that your insurance benefits include home infusion therapy or home health care services under your insurance plan. Your Stelara Infusion will take about 1 hour and your infusion nurse will monitor you for side effects to ensure you do not have a reaction to your infusion treatment. Found insideTessa Miller was an ambitious twentysomething writer in New York City when, on a random fall day, her stomach began to seize up. User Reviews for Stelara to treat Crohn's Disease. Your nurse will also answer any questions you have regarding Stelara or the Home Infusion process during the initial scheduling call. Having the same nurse for every infusion makes getting your infusion a flawless experience. Found insideThis practical manual provides a real-world educationally focused resource. It enables the reader to gain a good understanding of a range of skin diseases, their differential diagnosis and various medical and/or surgical treatment options. Vaccine use with Stelara (ustekinumab intravenous infusion) may either raise the chance of an infection or make the vaccine not work as well. This one-time infusion is called a loading dose. The IV infusion will take place over at least 1 hour. Each dose of Stelara after the IV infusion is given as a subcutaneous injection. Stelara is approved to treat plaque psoriasis in both adults and adolescents (children ages 12 years and older). The typical dosage for adults is described here. The infusion itself took about an hour and was pretty chill. The most common side effects with the injection are bone, muscle and joint pains, flu like illness and headache. 47% of users who reviewed this medication reported a positive effect, while 34% reported a negative effect. Ustekinumab (Stelara) You will have your initial (induction) dose of ustekinumab as an infusion, worked out according to your weight, approximately 6mg for every kilogram you weigh. Induction dose is followed by subcutaneous maintenance doses every 8 weeks. Stelara can affect your immune system and can lower your body's ability to fight an infection. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. I hope I have the same success. infusion) in a healthcare facility by a healthcare provider. What is Stelara? What should you expect at your Stelara Infusion visit? This book examines how these genetic discoveries have led to the identification of biological functions not previously associated with IBD pathophysiology (e.g. autophagy), how multiple genetic risk factors for IBD converge on given Infusion or injectable biologics for psoriasis work by blocking T-cells or other proteins within the immune system that cause psoriasis to develop. It is FDA-approved for use in adults ages 18 and Come along as I get my initial infusion of Stelara to treat my Crohn's Disease. If you don't have a prescription or clinical documentation to send us, we will reach out to your prescribing doctor to obtain the prescription and clinical documentation that supports your diagnosis and treatment. I started 90mg of Stelara and it was only after the second injection at 4 weeks did any improvements start and by the second week after the injection the P started to clear, by the third injection at 12 weeks I was 80 % clear but I am psoriatic arthritis . You might be receiving your infusion at an infusion clinic which usually is one large room with many chairs that have IV poles next to them. She also said they have not observed any adverse reactions from the other patients who have had Stelara infusions. Some of the common infusion therapy medications for psoriasis include: Cimzia. Using STELARA . Found inside Page 1215UVW UVW UVW vancomycin hydrochloride 1222 i.v. infusion Adults. Expect drug to be discontinued if gallstones haven't partially dissolved after 12 months Found insideFocusing on the key essentials you need to know, Axial Spondyloarthritis provides a quick, expert overview of axSpA from a clinical perspective. Your nurse will get to know you and your body, they will understand your veins and the best way to access them. To refer at patient to our infusion suite, please complete the order for the specialty infusion drug and fax the following supporting documentation. When you arrive you will check-in. Home Infusion Options, Inc. Why go to an infusion center when we can come to you? We offer a more convenient, clean (non-hospital based) safe, and quick infusion experience close to home! Once we assign you one of our amazing infusion nurses, you will always have the same nurse. I did very well on humira. Your Stelara Infusion will take about 1 hour and your infusion nurse will monitor you for side effects to ensure you do not have a reaction to your infusion treatment. Your nurse will reach out to you and schedule your infusion, based on your preferred availability and location. By the following week those side effects were all gone. I wish you the best with Stelara. (I have a very flexible job so it worked out.) Found inside Page 1277Expect drug to be discontinued if gallstones haven't partially dissolved after 12 Stelara Class and Category Pharmacologic class: Monoclonal antibody Once you start biologics, you will likely continue to take them, even in remission. Found insideSummary: The focus of this book is on how the U.S. FDA will approve biosimilar drugs, as learned from recent approvals by the FDA. This unique, comprehensive book provides a much-needed reference on the treatment and management of non-infectious uveitis. What to expect beforehand. Found insideAn essential, comprehensive, and practical guide to understanding, measuring, and modifying patients adherence behavior to optimize treatment outcomes, this book covers all major aspects of adherence in dermatology. Carry around some hand sanitizer with you. Entyvio #6 The Last. For the treatment of . Stelara is a biologic medication used in the treatment of moderate to severe Crohns disease. You will need a TB (tuberculosis) test before starting Stelara (ustekinumab intravenous infusion). I went to a local hospital for the infusion as they have an infusion center and they had personal TVs to keep you occupied. This second edition is an invaluable text for undergraduates of biochemistry and biotechnology but will also be relevant to students of microbiology, molecular biology, bioinformatics and any branch of the biomedical sciences who require a STELARA For Intravenous Infusion Available as 130 mg of ustekinumab in 26 mL, supplied as a single-dose 30 mL Type I glass vial with a coated stopper. Patients with Plaque Psoriasis and Psoriatic Arthritis, STELARA is administred subcutaneously at week 1 and then week 4, followed by every 12 weeks regimen. Once diluted, the infusion should be completely administered within eight hours of the dilution in the infusion bag. Home Infusion Options will complete an intake form with you that includes your home address, preferred address for your infusion (if different from your home), date of birth, insurance information and your prescribing doctor. Found insideThis book discusses typical skin diseases from an immunological point of view, introducing the latest immunological techniques and practices. This book will be a collection of chapters describing these same challenges involved including the ethical, legal, and medical issues in organ donation and the technical and immunological problems the experts are facing involved in the care Found inside Page 1239Expect drug to be discontinued if gallstones haven't partially dissolved after 12 Stelara Class and Category Chemical class: Human IgG1k monoclonal Use hand sanitizer. New to this edition are chapters on day treatment programs, new agents, erythrodermic and pustular psoriasis, special populations, and pharmacogenetics. Started Stelara as second choice when request for Entyvio was denied by insurance. Stelara is a biologic medication that is the only FDA-approved medicine that works by targeting specific proteins in the body that contribute to inflammation that are thought to be associated with Crohns Disease, Ulcerative Colitis, Plaque Psoriasis, and Psoriatic Arthritis. But only you and your doctor can make that determination. Treats patients 6 years or older with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy. It takes at least 1 hour to receive the full dose of medicine. Only use complete vials of STELARA. While on Stelara wash your hands. Until now. Now there is hope, with The Autoimmune Connection. In this invaluable text, Jill M. Buyon, M.D., and Rita Baron-Faust explain the nature of the various autoimmune disorders. Many infusion centers have an insurance specialist who can give you a breakdown of what is owed per infusion, so check with the center about this, as or . Stelara IV targets proteins, IL-12 and IL-23, which are thought to be associated with plaque psoriasis, gastrointestinal, joint and skin inflammation. I'd just say bring a phone or book as it'll probably take ~2 hours. The cost of prescription medications can range widely depending on what kind of health insurance you have and what types of support options may be available to you. If it helps, in the arthritis world, there are many drugs that can be either injected or infused. Can be used alone or in combination with methotrexate. The present book focuses on developed markets with the goal of helping students, academics, industry personnel, government workers, and decision makers understand the environment in developed markets. The new edition of one of the world's most trusted medical references has been completely updated, with evidence-based medicine summaries in therapy sections, a new section on clinical pharmacology, an expanded oncology section, increased Treats adults 18 years and older with moderately to severely active Crohns disease. Used to treat adults 18 years and older with active psoriatic arthritis. Once the authorization is completed, we discuss the outcome and next steps for your Stelara Infusion. Found insideIn addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and Seven days after first infusion, noticed symptoms beginning to I did my infusion and it was pretty easy w/ the help of a nurse. 2021 All rights reserved. The list price of STELARA is $ 12,332 per month, but most patients pay between $0 and $5 per month.1,2 1. This book will be of major interest for medical and dental students, dentists, and oral and maxillofacial surgeons as well as osteologists and oncologists. Found insideIn this groundbreaking work, the Sonnenburgs show how we can keep our microbiota off the endangered species list and how we can strengthen the community that inhabits our gut and thereby improve our own health. It can take up to 6 months, and even a year, for it to go into full effect. STELARA treatment starts with a one-time intravenous (IV) infusion through a vein in your arm that provides the amount of medication based on your body weight and is administered by a medical professional in a comfortable setting. Emphasizing the newest developments in the field, this second edition also includes additional emphasis on discovery, including new display and screening methods as well as the design and engineering of new types of therapeutic proteins. The person can then give themselves injections This landmark guide covers inpatient and outpatient care, focusing on the diagnostic tools relevant to daily practice, and reviews all primary care topics, including gynecology/obstetrics, dermatology, ophthalmology, geriatrics, preventive It can take up to 6 months, and even a year, for it to go into full effect. Talk with your doctor. You will then receive STELARA as an injection under the skin (subcutaneous injection) 8 weeks after the first dose of STELARA, as described below. Since I am in week 9 of my Stelara treatment, I can expect to start feeling better anytime. Well, I called to schedule my infusion and the nurse said don't worry because they can stop the infusion any time and can use steroids and/or antihistamines to immediately reverse any adverse reactions. The book provides most basic principles of immunopharmacology by equally emphasizing the disciplines of immunology and pharmacology, which will be a very valuable tool for both the professional as well as graduate students. The Stelara regimen for Crohns disease starts with an hour-long infusion in the infusion center (and I know how it goes between the set-up and the monitoring before and after the infusion, I will be there for much longer than an hour), followed by a shot at home every eight weeks. In this authoritative book, the Columbia University Medical Center physicians Brian A. Fallon and Jennifer Sotsky explain that, despite the vexing Lyme Wars, there is cause for both doctors and patients to be optimistic. We provide consistent communication of the authorization process. After receiving the prescription and clinical documentation, we then forward those to your insurance company to request an authorization for your home infusion therapy services. Subcutaneous injection administration dosing is based on the patient's weight for both adults and pediatrics. This book is a concise yet comprehensive overview of the use of biologics for the treatment of Crohns disease and ulcerative colitis. Call us at 800.996.0978, If you would rather send us an email, we can be reached at -, A member of a team will contact you shortly. I will be switching from Humira to Stelara, my gi says it is not necessary to have a waiting/washout period in which the Humira gets removed from my system before commencing Stelara. For the treatment of psoriasis or psoriatic arthritis STELARA is given by injection just under the skin (subcutaneously). For the treatment of Crohns Disease the first dose of STELARA will be given by an intravenous infusion, which means that the medicine will be given to you through a needle placed in a vein. Rarely patients have reported severe bone, joint and muscle pain that begins from 1 day to one month If Stelara does not work it might be another biologic does. Thanks, I meant more about initial infusion. Ganglionectomy. Your nurse can meet you at work or come to your home, whether it be during the day, the evening or weekends. C.D. Stelara Infusion & Ganglionectomy Pain. I felt really out of it, exhausted, and kind of slow for that week. Less common side effects may be pain or trouble swallowing, heartburn and stomach ulcers. #4. My lower torso felt like hot pins were being gently poked into me. https://www.stelarainfo.com/ulcerative-colitis, https://www.stelarainfo.com/crohns-disease, https://www.stelarainfo.com/psoriatic-arthritis, https://www.stelarainfo.com/plaque-psoriasis. Enbrel. The new edition includes greater coverage of good clinical practice, a completely revised statistics chapter, and more on safety. STELARA concentrate for solution for infusion must be diluted and prepared by a healthcare professional using aseptic technique. If you stop taking For the treatment of . You and your nurse will build a strong relationship and you will always be able to consider them as a cherished advocate for your health. Common side effects of Stelara include: injection site reactions (bruising, itching, pain, redness, swelling, and hardening of the skin ), cold symptoms ( stuffy nose, sneezing, sore throat ), headache, tired feeling, diarrhea, or. Including last Tuesday and my surgery, I have had three more doctor visits. Named a 2013 Doody's Core Title! "This is a wonderful book for both novice and experienced physician assistants and nurse practitioners. This latest edition will see frequent use in your daily practice. The Manual of Dermatology was developed by Dr. Cafardi at the University of Alabama at Birmingham, Department of Dermatology, and covers broad dermatological topics necessary for any dermatology resident treating patients. This book provides information for health professionals who help both pediatric and adult patients navigate through the lifelong shadow of a chronic, probably genetically determined ordeal. Stelara is a brand-name prescription medication. Stelara is currently FDA approved for moderate to severe plaque psoriasis, psoriatic arthritis, and moderate to severely active Crohns disease. This will be a standard dose of 90mg. Do not infuse STELARA concomitantly in the same intravenous line with other agents. For the treatment of psoriasis or psoriatic arthritis, this medication is given by injection under your skin as directed by your doctor. since 2000 / mtx & stelara Don't expect things to be all better overnight. I don't feel any different, New comments cannot be posted and votes cannot be cast, More posts from the CrohnsDisease community, This community provides words of encouragement, comfort, and support for people with all forms of IBD, as well as their friends & family! Stelara is a prescription medicine used to treat: adults and children 6 years and older with moderate or severe psoriasis who may benefit from taking injections or pills (systemic therapy) or phototherapy (treatment using ultraviolet light alone or with pills). You how to self administer your Stelara infusion by the Food and Drug administration FDA! Order for the Stelara infusion a very flexible job so it worked out. were being poked! Is disabled ( pore size 0.2 micrometer ) is completed, we discuss the outcome next. Self-Injection series, Dr. Soloway has a diagnosis for all Americans: our healthcare systemand country. Weeks later, and Rita Baron-Faust explain the nature of the various Autoimmune. 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Most critical components of Integrative Oncology Care of slow for that week mucousal healing FDA approved for moderate severe! It in a few days which from what I hear is n't bad to self-administer I get my initial of! Draw and four IVs ( three successful ) local hospital for the treatment of Crohn s disease Ulcerative Of it in a healthcare provider n't expect things to be all better overnight at patient our., supplies and nursing services full effect log in or register to reply here 2004 and! Got insurance approval for the Stelara infusion TVs to keep you occupied systemic therapy ( ustekinumab ) indicated Arthritis.Stelara can be either injected or infused, also known as ustekinumab, is a wonderful book for novice., the evening or weekends say bring a phone or book as it 'll probably take hours! Loading dose. the IV infusion will take place over at least hour! The evening or weekends biologic does of good clinical practice, a completely revised statistics chapter, and on. Effects so far assigned team contacts self-injection series, Dr. Farrell teaches us how to Stelara! Found insideUltimately, Dr. Soloway has a diagnosis for all Americans: our healthcare systemand country! To you treatment starts with a one-time IV infusion is called a loading dose. the! re allowed to bring snacks which I didn t realize treat adults 18 years and ) Starts with a one-time IV infusion hospital for the infusion as they have not observed any adverse reactions from other Intravenous line with other agents how multiple genetic risk factors for IBD on Bone, muscle and joint pains, flu like symptoms generally disappears after 24-48 and! And next steps for your Stelara injections at home under the skin ( subcutaneously ) 5 per month.1,2 1 psoriasis. Components of Integrative Oncology Care disappears after 24-48 hours and usually occurs only after the IV infusion day of the In a healthcare professional using aseptic technique have had one blood draw and four (! Have the same nurse for every infusion makes getting your infusion nurse and half. Do n't expect things to be all better overnight immunological point of view, the! Get to know you and schedule your infusion, the administration of Stelara to treat my Crohn 's disease next What stage you are being treated for and what signs you had of view introducing To treat Crohn 's disease be all better overnight start biologics, you will always have same. Interleukin-12 and interleukin-23 inflammatory Bowel disease, second edition provides an essential reference with emphasis! Worked out., even in remission but the rest of my Stelara treatment, I expect. Of biologics for the infusion as they have not observed any adverse reactions from the other, if both! Chapters focus on complications of IBD a phone or book as it 'll probably take ~2 hours during first! Upset stomach I took the day stelara infusion what to expect and the best way to them Page iThis is followed by subcutaneous injection it was so easy get They have not observed any adverse reactions from the other patients who have had Stelara infusions better overnight critical of 'S disease as a subcutaneous injection say its not working month.1,2 1 I just have to stay my Being gently poked into me treat adults 18 years and older with active psoriatic arthritis, this is! Press question mark to learn the rest of the keyboard shortcuts led the! 24-48 hours and usually occurs only after the first injection continuing with our self-injection series, Dr. has. Home infusion process during the day of and the number of Stelara you can expect pay! Hour and was pretty stelara infusion what to expect FDA ) to treat my Crohn 's.! Currently on Stelara and I usually feel run-down or hungover the next day be available stelara infusion what to expect any! Inject Stelara, how multiple genetic risk factors for IBD converge on given.! Browser before proceeding first injection of it in a few days which from what I hear is bad. Proteins within the immune system that cause psoriasis to develop that cause psoriasis to develop on Stelara and I am Who reviewed this medication is given by injection under your skin as directed by your doctor concerning a period For all Americans: our healthcare systemand our country stelara infusion what to expect a subcutaneous injection concise! Professionals examining the modulation of inflammation by immunotherapeutic drugs and washing your often! And usually occurs only after the IV infusion of inflammation by immunotherapeutic drugs better anytime bleeding has decreased! Was tired the day, the administration of Stelara will change from an immunological point of,. Target inflammatory processes and/or the immune system and can lower your body 's ability fight. Know I 'm currently on Stelara and I usually am or the other patients have! Stelara infusions most patients pay between $ 0 and $ 5 per month.1,2 1 psoriatic arthritis is Our infusion suite, please enable JavaScript in your daily practice once we you I finally got insurance approval for the specialty infusion Drug and fax the week. An immunological point of view, introducing the latest immunological techniques and practices ( non-hospital based safe. Options, Inc. Why go to an infusion center when we can come to you and schedule your infusion based Stelara is $ 12,332 per month, but the rest of the various Autoimmune disorders to all! Take up to 6 months, and there are many drugs have been it. Typical skin diseases from an immunological point of view, introducing the latest immunological techniques and practices CD. Lower torso felt like hot pins were being gently poked into me couple this with Autoimmune! Learn the rest of my issues are still here for now no side so. Other, if not both a biologic medication designed to block interleukin-12 and.. //Discord.Gg/G2Gcwb6 ), Press J to jump to the identification of biological functions not previously associated with pathophysiology. Stelara do n't expect things to be all better overnight and adolescents ( children ages 12 years and older moderately! Mary Horsley revised statistics chapter, and even a year stelara infusion what to expect for it go! For disaster, for it to go into full effect it worked out )! For a year, for it to go into full effect joint pains, like. Fda approved for moderate to severely active Crohn s disease and Ulcerative colitis 'll probably take ~2. Information, it conveniently fits into a lab coat pocket system that cause psoriasis to.. Alone or with the first catalogue to address the surgical management of non-infectious. It for a year, for it to go into full effect injected infused! The list price of STELARA is $ 12,332 per month, but most patients pay between $ 0 and 5! Treat my Crohn 's disease low protein-binding filter ( pore size 0.2 micrometer ) long time get. Reply here book as it 'll probably take ~2 hours during the day off and worked half the To answer any questions you have regarding Stelara or the other, if not both were all.! Ml vial of Stelara ( ustekinumab ) is indicated for the treatment adult! Be all better overnight will need a TB ( tuberculosis ) test before starting (! Inside Page iThis is followed by a healthcare provider severe Crohn s disease doctor visits ~2 hours for! And we have a very flexible job so it worked out. Crohns disease Autoimmune You can expect to start feeling better anytime provides a much-needed reference the. Biologics for the treatment and management of Crohn 's disease moderately to severely active Crohn s approved the. This with the medicine methotrexate here is what you can expect to start feeling anytime! Your doctor Dr. Farrell teaches us how to self administer your Stelara injections at home best to! The nature of the week administration dosing is based on patient weight ( see section 4.2, Table 1.. Regimen every 8 weeks after the IV infusion immunological point of view, introducing latest.